Pulmonary arterial hypertension treprostinil

The synthetic analogues of prostacyclin, be-raprost, treprostinil and iloprost, although also platelet aggregation inhibitors, are used to treat pulmonary arterial hypertension. 

Tapson VF, Gomberg-Maitland M, McLaughlin VV, et al. Safety and efficacy of IV treprostinil for pulmonary arterial hypertension. A prospective, multicenter, open-label, 12-week trial. Chest 2006 129 683-8. 

Barst RJ, Galie N, Naeije R, et al. Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil. Eur Respir J 2006 28(6) 1195-203. 

Currently, prostanoids are administered for various therapeutic interventions e.g., 1) treprostinil, beraprost, and iloprost (Fig. 3) are analogs of PGI2 (prostacychn) which are used to treat pulmonary arterial hypertension (PAH) to overcome the drawback of short circulation... 

---