Pulmonary alveolar proteinosis surfactants

Pulmonary alveolar proteinosis Surfactant protein C (SP-C) Local... 

Pulmonary alveolar proteinosis Lung surfactant protein C Local... 

Lung surfactant protein C Res 9-22 (WWVVVLVVVVIV) (deMeUo and Lin 2001 Hosia et al. 2002 Schmitt-Bemard et al. 2000 Seymour and PresneiU 2002 Trapnell et al. 2003) Pulmonary alveolar proteinosis... 

Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of surfactant-like material in the alveolar spaces, with resultant impairment in gas exchange (1-8). Since the sentinel description of PAP by Rosen and colleagues in 1958 (9), fewer than 500 cases have been reported in the literature (5). 

Singh G, Katyal SL, Bedrossian CW, et al. Pulmonary alveolar proteinosis. Staining for surfactant apoprotein in alveolar proteinosis and in conditions simulating it. Chest 1983 83(l) 82-86. 

Brasch F, Brrzele J, Ochs M, et al. Surfactant proteins in pulmonary alveolar proteinosis in adults. Eur Respir J 2004 24(3) 426-435. 

Nogee LM, de Mello DE, Dehner LP, et al. Brief report deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis. N Engl J Med 1993 328(6) 406 10. 

Seymour IF, Doyle IR, Nakata K, et al. Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis. Thorax 2003 58(3) 252-257. 

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