Pteroylpolyglutamate

BHANDARI s D, GREGORY J F 3rd (1990) Inhibition by selected food components of human and porcine intestinal pteroylpolyglutamate hydrolase activity. ,4m J Clin Nutr. 51 87-94. 

Enzymes that hydrolyze the polyglutamate side chain of pteroylpolyglutamates are important in the bioavailability of dietary pteroylpolyglutamates. This assay uses the pentaglutamate derivative as substrate, and all intermediates on the pathway to pteroylmonoglutamate are detected. 

A precursor of tetrahydrofolic acid is also pteroylpolyglutamic acid (D 23) from which the excess glutamic acid residues are removed by hydrolytic cleavage. 

Pteroylpolyglutamic acids are vitamins for animals (E 2.1). They are used in the formation of tetrahydrofolic acid (D 10.4.2). 

Pteridines T etrahy drobiopterin, tetrahydrofolic acid (D 10.4.2) Coenzymes of monooxygenases (C 2.6.1), of formyltransferases and certain methyltransferases (C 3.2), in humans synthesized from the vitamin folic acid or from pteroylpolyglutamic acids... 

I Eto, CL Krumdieck. Determination of three different pools of reduced one-car-bon-substituted folates. III. Reversed-phase high-performance liquid chromatography of the azo dye derivatives of p-aminobenzoylpolyglutamates and its application to the study of unlabeled endogenous pteroylpolyglutamates of rat liver. Anal Biochem 120 323-329, 1982. 

Lavoie, A., Tripp, E. and Hoffbrand, A. V. (1974) The effect of vitamin B deficiency on methylfolate metabolism and pteroylpolyglutamate synthesis in human cells, Clin. Sci. 

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