Psychomotor impairment Motor activity

The concurrent use of fluoxetine 30 to 60 mg and alcohol (4 oz of whiskey) did not affect the pharmacokinetics of either drugs in healthy subjects, and fluoxetine did not alter the effect of alcohol on psychomotor activity (stability of stance, motor performance, manual co-ordination). Similarly, blood-alcohol levels of 80 mg% impaired the performance of a number of psychomotor tests in 12 healthy subjects, but the addition of fluoxetine 40 mg daily taken for 6 days before the alcohol had little further effect. Another study also found no change in the performance of a number of psychophysiological tests when fluoxetine was combined with alcohol. No problems were found in a study of 20 alcohol-dependent patients taking fluoxetine 60 mg daily when they drank alcohol, or in approximately 31 patients taking fluoxetine 20 mg daily who drank unspecified small quantities of alcohol. ... 

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