Psycholeptic drugs

Psycholeptics Drugs used in diabetes Antibiotics - systemic... 

A complete listing of all the psycholeptic drugs would, of course, also include the older depressants and hypnotics such as the bromides, chloral hydrate, and morphine. 

Reserpine, Chlorpromazine and other Psycholeptic Drugs Reserpine depletes postganglionic sympathetic fibres of their noradrenaline and the peripheral sympathetic responses of animals which have been pretreated with reserpine are those which would be expected to follow loss of sympathetic transmitter . Thus, in adrenalectomized, reserpinized cats, stimulation of the splanchnic nerves does not produce the increase in blood pressure which is seen in non-reserpinized animals. Hexamethonium normally produces hypotension due to ganglionic blockade in the reserpinized animal it is without effect. Reserpine also causes a loss of adrenaline from the adrenal medulla. Since this adrenaline is liberated into the blood stream, it is not surprising that reserpine causes hyperglycaemia. 

PSYCHOTROPIC DRUGS AND NEUROHUMORAL SUBSTANCES Table 5.3. Miscellaneous psycholeptic drugs... 

It was found that psycholeptic drugs, such as haloperidol and chlorpromazine, block the dopamine receptor in mouse brain (Carlsson and Lundqvist, 1963 van Rossum, 1966), and this antagonism was found to take place also in the schizophrenic patient (Horn and Snyder, 1971). The clinically beneficial effects of flupethixol (a thioxanthene) are confined to the as-isomer, the one that blocks the dopamine receptor in vitro (Crow and Johnstone, 1977). Patients overdosed with psycholeptics show parkinsonian symptoms. While there is little doubt that schizophrenia is accompanied by excessive and deleterious accumulation of dopamine in the striatum and possibly other parts of the brain, the biochemical cause of... 

Anti-depressant drugs. Because a quite different class of psychotherapeutic agent, the anti-depressant, shares the three-ring system with the psycholeptics, an exploration was made of the structure-action relations in the two systems (Wilhelm and Kuhn, 1970). The topology of the tricyclic skeleton determines the type of activity, but this is modified by the side-chain. 

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