PSRs Prepared by Solid-Phase Chemistry

Covalent Linkage Between the Active Species and Support 5.2.1.1 PSRs Prepared by Solid-Phase Chemistry 

A covalent linkage between the active moiety and the support guarantees a nonleaking reagent, and thus fulfills one of the most important requirements for PSR technology applications. Solid-phase organic chemistry is used for the preparation 

The polymeric phenols 3 proved to be recyclable. A sample was reactivated for three reaction cycles using benzoyl chloride 2 as acylating agent. Coupling with benzylamine was used to determine the loading, which was found to be virtually identical for all three cycles [13]. 

Preparation of the polymer [19] A solution of aluminum trichloride (25 g, 0.18 mol) in dry nitrobenzene (200 mL) was added to a mixture of macro-reticular polystyrene 1 (50 g, 0.48 mmol) and 4-chloro-3-nitrobenzoyl chlo- 

Hydrolysis was carried out with a mixture of 40 % benzyltrimethylammon-ium hydroxide in water, water (130 mL), and dioxane (260 mL) at 90 °C for 8 h. The polymer 3 was filtered off and the process was repeated. The beads were finally washed with dioxane, acetic acid, and dichloromethane/methanol (2 1). 

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