Preparation and Use of PSRs

Various types of PSRs are described in the following sections. However, rather than classify these reagents by the type of support or by functionality, a classification based on the method of preparation is used here, with the focus on the most commonly employed techniques. Furthermore, rather than providing an exhaustive list of all PSRs described in the literature, the aim of this chapter is to provide an understanding of the principles of preparation and application of such reagents, with a special focus on important reactions and on the combination of several PSRs in one synthetic sequence or, where possible, in one pot. The latter is a rather novel and highly interesting aspect of combinatorial chemistry applications. 

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Much later, Hofmann described the preparation of pure phosphine from phosphonium iodide, PH4I, and the use of t iodide in the synthesis of alkyl phosphines. The preparation of phosphinic acids, PSRs-SH, by the action of sulphur on primary and secondary phosphines was described by Hofmann and Mahla. ... 

A covalent linkage between the active moiety and the support guarantees a nonleaking reagent, and thus fulfills one of the most important requirements for PSR technology applications. Solid-phase organic chemistry is used for the preparation... 

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