Pseudomonas pyocyanea

The effect of replacement of the APA nucleus with an ACA nucleus on the susceptibility of the substrate to enzymic hydrolysis depends on the nature of the /3-lactamase 2). It has been richly illustrated in the case of the /3-lactamase of Pseudomonas pyocyanea (31) and analyzed in terms of conformative response (see Section IV,B) in a study of a B. cereus /3-lactamase (75). In that study the role of the nucleus was examined in both catalytic and noncatalytic enzyme-substrate interactions. Little has been published on the effect of modifications within each nucleus, presumably because such modifications lead, as a rule, to the loss of antibiotic activity. 

Conversion of the carboxyl groups in penicillins confers partial resistance to /3-lactamase (85-87). In cephalosporins, replacement of the acetyl group in position 3 of the dihydrothiazine ring [R in Fig. 1, (III)] by pyridine causes increased susceptibility to hydrolysis by /3-lactamases of Pseudomonas pyocyanea (31, 88), Enterobacter cloacae (45), E. coli (42, 88), and both the extracellular and cell-bound enzymes of B. cereus (38). 

An extract of bog myrtle has been shown to have a suppressant effect on influenza A virus and a bacteriophage of Pseudomonas pyocyanea. 

The antimicrobial activity of the fibers was tested against three cormncm strams of bacteria, i.e., Candida albicans, Ste hylococcus aureus and Pseudomonas pyocyanea. The bacteria were suspended in 0.5% peptone water with the bactoia concentration at about 1.5xl0 to 1.5x10 cfii/rrd. 35 ml 0.5% peptone water were measured into lOQml conical flasks and to each of ftiem wme added 2.5ml of the bactraia suspoision, with the bacteria concentration in the conical flask controlled at between 1x10 and 1x10 ... 

Other authors (52) have generalized and have stated that no bacterium when once infected can multiply. Contrary statements in the literature are attributed to inadequate infection. However, Lwoff and collaborators have since reported bacterial growth preceding phage lysis in BacUlus megatherium (207), Pseudomonas pyocyanea,... 

Activity as bactericide (9I, 622) against Aerobacter aerogenes (893) Achromo-bacter, Brevibacterium, Flavobacterium, Micrococcus, Pseudomonas, Sarcina (1275) intestinal bacillus (275) Staphylococcus aureus (91> 275) Bacillus proteus, Escherichia coli. Pseudomonas pyocyanea (11 5) ... 

Activity as bactericide against Bacillus proteus, Escherichia coli. Pseudomonas pyocyanea (11 5) Staphylococcus aureus (2966). 

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