Pseudomonas normal flora

Tetracyclines modify the normal flora, with suppression of susceptible coliform organisms and overgrowth of pseudomonas, proteus, staphylococci, resistant conforms, Clostridia, and Candida. This can result in intestinal functional disturbances, anal pruritus, vaginal or oral candidiasis, or enterocolitis with shock and death. 

Figure 4 shows the change of bacterial species in the sputum of patients with DPB before and after treatment. With the conventional treatment H. influenzae decreased and P. aeruginaosa increased after therapy. EM therapy reduced both Haemophilus and Pseudomonas organisms and increased normal flora. 

Penicillins alter the normal bacterial flora in areas of the body, including the respiratory and intestinal tracts. Patients taking oral penicillins may experience nausea, vomiting, or diarrhea. This is usually of little clinical significance because the normal microflora reestablishes itself quickly after cessation of therapy. However, serious superinfection with resistant organisms such as Pseudomonas, Proteus, or Candida can follow long-term therapy with any penicillin. Superinfection with Clostridium difficile can lead to potentially fatal pseudomembranous colitis. 

The range of nutritional requirements of microorganisms found as normal microbial flora is a reflection of their ecological niches. For example. Staphylococcus epidermidis, the predominant skin surface-colonizing bacterium, requires several amino acids and vitamins that are common on the skin surfaces. However, microorganisms common in both soil and water are much less fastidious. They can achieve their organic requirements from simple carbon compound sources widely available in the body, as well as in the natural environment. Both Escherichia coli and Pseudomonas spp. are examples of bacteria that can thrive on very nutrient-minimal media [10]. 

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