Bupropion Pseudoephedrine

Acute coronary sjmdrome has been attributed to a combination of pseudoephedrine with amfebutamone (bupropion) (33). 

Pederson KJ, Kuntz DH, Garbe GJ. Acute myocardial ischemia associated with ingestion of bupropion and pseudoephedrine in a 21-year-old man. Can J Cardiol 2001 17(5) 599-601. 

Clinically important, potentially hazardous interactions with amitriptyline, amoxapine, amphetamines, bupropion, citalopram, clomipramine, cyproheptadine, desipramine, dextroamphetamine, dextromethorphan, diethylpropion, dopamine, doxepin, entacapone, ephedra, ephedrine, epinephrine, fluoxetine, fluvoxamine, ginseng, imipramine, levodopa, mazindol, meperidine, methamphetamine, nefazodone, nortriptyline, paroxetine, phendimetrazine, phentermine, phenylephrine, pizotifen, propoxyphene, protriptyline, pseudoephedrine, rizatriptan, sertraline, sibutramine, sumatriptan, sympathomimetics, tramadol, tricyclic antidepressants, trimipramine, tryptophan, venlafaxine, zolmitriptan... 

Amphetamines 2-5 days Up to 2 weeks with prolonged or heavy use Many sympathomimetic amines such as pseudoephedrine, ephedra, phenylephrine, fenfluramine, and phentermine may cause positive results. Other drugs such as selegiline, chlorpromazine, trazodone, bupropion, and amantadine may cause false-positive results depending on the assay. 

Fora report of acute myocardial ischaemia attributed to combined use of bupropion, nicotine (from smoking) and pseudoephedrine, see Bupropion + Pseudoephedrine , below. 

An isolated report describes acute myocardial ischaemia associated with bupropion, nicotine and pseudoephedrine. 

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