Pseudo-protein models

Model Compounds Very few ferrous complexes having non-porphyrin ligands react with dioxygen to form stable adducts. Unlike the pseudo-heme model complexes, all of the adducts prepared so far appear to be peroxo rather than superoxo species. To mimic the protein fragment on the non-heme proteins multidentate... 

Peroxidases are haem proteins that are activated from the ferric state to one-electron oxidants by H202. They play a significant role in the generation of radicals from xenobiotics. The compound I state contains one oxidising equivalent as an oxoferryl-haem entity and the second as a porphyrin -radical cation. Upon the oxidation of a substrate the porphyrin radical is repaired, giving the compound II. Reduction of the oxoferryl haem back to the ferric state by a second substrate molecule completes the enzyme cycle. In addition to the classical peroxidases, several other haem proteins display pseudo-peroxidase activity. The plant enzyme horseradish peroxidase (HRP) is often employed in model systems. 

---