Pseudo-acyclic molecule

Fig. 9.7 A pseudo-acyclic molecule is generated by breaking the ring.

The systematic search is most efficient when the rotatable bonds are processed in a unidirectional fashion. This ensures that once an atom has been fixed in space relative to the atoms already considered then it will not be moved again. For an acyclic molecule this means that the search starts at one end of the molecule and moves down the chain. Molecules containing rings are treated by opening the cycles to give the pseudo-acyclic molecule as described above and then processed (Figure 9.9),... 

Shaabani reported a pseudo-five-component synthesis of 4,5,6,7-tetrahydro-l/f-l,4-diazepine-5-caiboxamide derivatives 79 from 2,3-diaminomaleonitrile, a cyclic or acyclic ketone, an isocyanide and a molecule of water in the presence of a catalytic... 

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