Prozac, formulation

Maprotiline, Moclobemide, Mianserin, Fluoxetine (Prozac), Paroxetine, Sertraline, Fluvoxamine, Citalopram, Venlafaxin (generic IR formulation and the brand Venlafaxine XR), Mirtazapine, Flupentixol-melitracen (Deanxit), Tianeptine, Extract of St. John s Wort, Buspirone Depression and anxiety... 

Another example in which the excipient reacts with the API is the reaction between lactose and fluoxetine hydrochloride (refer to Figure A15-6 in the Addendum of this chapter). This is a typical example of the Maillard reaction [9]. Another example of the Maillard reaction is presented where Prozac (fluoxetine hydrochloride) and two generic drug products of Prozac were compared at accelerated conditions (40°C/75% RH), and the amount of degradation products (analyzed by HPLC) were found to be very different between the studied formulations (refer to Table 15-2) [10]. The authors... 

Inspection of the synthetic methods described in Sections 21-5 through 21-8 may give you further ideas about how to tackle the synthesis of Prozac, but they are all variations on the schemes formulated so far. However, consideration of the Mannich reaction (Section 21-9) provides a more fundamental alternative, attractive because of its more highly convergent nature to a derivative of compound B with the intact amino function in place. Indeed, this is the commercial route used by Eli Lilly to the final drug. 

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