Proton pump inhibitors systematic reviews

Proton pump inhibitors A systematic review of the evidence has suggested that omeprazole reduces the antiplatelet effects of clopidogrel, probably by competitive inhibition of CYP2C19, that the interaction is clinically significant, and that it may not be shared by other proton pump inhibitors [17SM] reviewers have concluded... 

Leontiadis GI, Sharma VK, Howden CW. Systematic review and meta-analysis proton pump inhibitor treatment for ulcer bleeding reduces transfusion requirements and hospital stay-results from the Cochrane Collaboration. Aliment Pharmacol Ther 2005 22 169-74. 

ZacnyJ, Zamakhshary M, Sketris I, et al. Systematic review the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-esophageal reflux disease patients. Aliment Pharmacol Ther. 2005 21 1299-1312. 

Kenneth R, McQuaid and Loren Laine. Early heartburn relief with proton pump inhibitors A systematic review and meta-analysis of clinical trails. Clinical Gastroenterdogy and Hepatology 2005, 3, 553-563. 

Leontiadis, G.I. et al., Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. Health Technol Assess, 11(51) iii-iv, 1-164, 2007. 

Systematic reviews Laboratory and chnical evidence suggest that the increase in gastric pH caused by proton pump inhibitors may be linked to increased bacterial colonization of the stomach and may predispose patients to an increased risk of respiratory infections. The association of proton pump inhibitors (esomeprazole, rabeprazole, pantoprazole, and omeprazole) with respiratory infections has been studied in a systematic review of seven studies, four of which showed a trend towards an association, although most of the studies failed to show a significant correlation [54 ]. 

Sultan N, Nazareno J, Gregor J. Association between proton pump inhibitors and respiratory infections a systematic review and meta-analysis of chnical trials. Can J Gastroenterol 2008 22 761-6. 

Jarupongprapa S, Ussavasodhi P, Katchamart W. Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors a systematic review and meta-analysis. J Gastroenterol July 2013 48(7) 830-8. 

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