Proton magnetic resonance syndrome

Miyaoka T, Yasukawa R, Mizuno S, Sukegawa T, Inagaki T, et al. 2005. Proton magnetic resonance spectroscopy (lh-mrs) of hippocampus, basal ganglia, and vermis of cerebellum in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (gilbert s syndrome). J Psychiatr Res 39 29-34. 

A genetic disease, the 18q-syndrome is a rare leukodystrophy presenting a genomic deletion that includes the MBP gene. Proton magnetic resonance data indicate demyelination or increased myelin turnover rather than dysmyelination (Hausleretal., 2005). 

Murphy DGM, Critchley HD, Schmitz N, McAlonan G, van Amselsvoort T, Robertson D, Daly E, Russell A, Simmons A, Murphy KC, Howhn P (2002) Asperger syndrome. A proton magnetic resonance spectroscopy study of brain. Arch Gen Psychiatry 59 885-891. 

Haley RW, Fleckenstein JL, Marshall WW, et al Effect of basal ganglia injury on central dopamine activity in Gulf War syndrome correlation of proton magnetic resonance spectroscopy and plasma homovanillic acid levels. Arch Neurol 57 1280-1285,2000... 

Several methods are available in the literature for the measurement of aliphatic amines in biological samples [28]. Problems with specificity and separation and cumbersome derivatisation and/or extraction procedures have limited the use of these techniques on a larger scale in clinical practice. The lack of a simple analytical method may have led to an underestimation of the incidence of the fish odour syndrome. For diagnosing the syndrome, an analytical technique should be used that is able to simultaneously and quantitatively measure TMA and its N-oxide in the complex matrix of human urine. Two such methods are currently available for this purpose proton nuclear magnetic resonance (NMR) spectroscopy and head-space gas analysis with gas chromatography or direct mass spectrometry (see below). 

Eugene, M. (1998) [Diagnosis of fish odor syndrome by urine nuclear magnetic resonance proton spectrometry]. Ann Dermatol Venereol 125, 210-212. 

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