Protofibrils, keratin, structure figure

FIGURE 4-11 Structure of hair, (a) Hair a-keratin is an elongated a helix with somewhat thicker elements near the amino and carboxyl termini. Pairs of these helices are interwound in a left-handed sense to form two-chain coiled coils. These then combine in higher-order structures called protofilaments and protofibrils. About four protofibrils—32 strands of a-keratin altogether—combine to form an intermediate filament. The individual two-chain coiled coils in the various substructures also appear to be interwound, but the handedness of the interwinding and other structural details are unknown, (b) A hair is an array of many a-keratin filaments, made up of the substructures shown in (a). 

Figure 2.25. Structure of keratin protofibrils. The diagram illustrates the structure of keratin in intermediate filaments containing a helical sequences. Two coils are wound around each other and then packed into protofilaments. Eight protofilaments are packed into a filament.

There are some 20 amino acids in nature, see Figure 14.29. These are organized into an a-helix in the fibrous proteins, which in turn are combined to form protofibrils as shown. In addition to being crystalline, the fibrous proteins are cross-linked though disulfide bonds contained in the cystine amino acid mer, which is especially high in keratin. Animal tendons, composed of collagen, another fibrous protein, have also been shown to have a surprisingly complex hierarchical structure (166). 

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