Protoberberine nucleic acids

Interaction of Protoberberine Alkaloids with Nucleic Acid Structures. . . 176... [Pg.155]

Protoberberine Alkaloid-Triplex Nucleic Acid Interaction. 194... [Pg.156]

Protoberberine Alkaloid-Nucleic Acid Quadruplex Interaction. 196... [Pg.156]

Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties 157... [Pg.157]

Maes BUW (2006) Transition-Metal-Based Carbon-Carbon and Carbon-Heteroatom Bond Formation for the Synthesis and Decoration of Heterocycles. 1 155-211 Maiti M, Kumar GS (2007) Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties. lO. 155-210... [Pg.312]

Berberine chloride was evaluated for antimalarial activity against Plasmodium falciparum in vitro (two clones of human malaria Plasmodium falciparum D-6 [Sierra Leone clone] and W-2 (Indochina clone) and Plasmodium berghei in vivo (mice). The alkaloid exhibited an antimalarial potency equivalent to that of quinine in vitro, but was inactive in vivo. The results were consistent with those of others who have found berberine to be a potent inhibitor in vitro of both nucleic acid and protein biosynthesis in P. falciparum, and have demonstrated a strong interaction of berberine with DNA. In addition, the lack of in vivo antimalarial activity in mice observed with berberine and other protoberberine alkaloids agrees with clinical reports that have claimed berberine to be inactive as an antimalarial drug [228]. [Pg.130]

Big Chemical Encyclopedia