Proteus syndrome

PTEN Cowden disease, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, Lhermitte-Duclos disease overgrowths of various organs, hamartomas of the skin, mucosa, cerebellar cortex high risk of developing several types of cancer. Spontaneous pten mutations found frequently in human cancers... 

An inherited mutation in NF-1 can lead to neurofibromatosis, a disease primarily of numerous benign, but painful, tumors of the nervous system. The movie Elephant Man was based on an individual who was believed to have this disease. Recent analysis of the patient s remains, however, indicates that he may have suffered from the rare Proteus syndrome, and not neurofibromatosis. 

Gastrointestinal vascular anomalies are often associated with known syndromes such as Klippel-Trenaunay, Rendu-Osier-Weber, blue rubber bleb nevus, and Proteus syndromes. 

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