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Proteomics chemical techniques

The dynamic range of protein expression represents a main obstacle since abundant proteins are seldom of interest and others such as transcription factors are only present in a few copies. There is no detector that is able to visualize all proteins at the same time so that prefractionation and the investigation of subproteomes is required. In fact, pre-MS sample preparation techniques exploiting electrophoretic, chromatographic, or chemical properties of the analyte are often the bottleneck of proteomics. [Pg.249]

The rapid progress in proteomics and peptidomics during the last decade offers us new possibilities to study clinical aspects of disorders and diseases related to the brain [1], These strategies also offer new tools to follow chemical modifications and altered metabolic disturbances that may be indicative of pathophysiological adaptations related to environmental and psychosocial prolonged stress. These techniques can contribute to developments in the diagnostic and therapeutic fields of psychiatric... [Pg.323]

See other pages where Proteomics chemical techniques is mentioned: [Pg.114]    [Pg.504]    [Pg.1029]    [Pg.19]    [Pg.649]    [Pg.115]    [Pg.409]    [Pg.34]    [Pg.35]    [Pg.173]    [Pg.298]    [Pg.141]    [Pg.88]    [Pg.380]    [Pg.190]    [Pg.232]    [Pg.14]    [Pg.213]    [Pg.3]    [Pg.76]    [Pg.89]    [Pg.22]    [Pg.40]    [Pg.157]    [Pg.177]    [Pg.18]    [Pg.73]    [Pg.370]    [Pg.303]    [Pg.125]    [Pg.133]    [Pg.515]    [Pg.8]    [Pg.11]    [Pg.1725]    [Pg.833]    [Pg.74]    [Pg.27]    [Pg.50]    [Pg.353]    [Pg.418]    [Pg.328]    [Pg.291]    [Pg.34]    [Pg.133]    [Pg.73]    [Pg.387]   
See also in sourсe #XX -- [ Pg.18 ]



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