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Proteins protecting groups

Many protective groups have been developed for the amino group, including carbamates (>NCO,R), used for the protection of ammo acids in peptide and protein syntheses, and amides (>NCOR). used more widely in syntheses of alkaloids and for the protection of the nitrogen bases adenine, cytosine, and guanine in nucleo-... [Pg.315]

Tnflic acid is a useful reagent for the removal of protecting groups (deblocking) in synthetic proteins [67] At the same time, it is an excellent catalyst for the protection of a variety of phenols in the form of their terf-butyl ethers [5(5] (equation 37)... [Pg.954]

Laurell, C.B. (1985). Acute phase proteins - a group of protective proteins. In Recent Advances in Clinical Biochemistry , No. 3 (eds. C.P. Price and K.G.M.M. Alberti) pp. 103-124. Churchill Livingstone, Edinburgh. [Pg.110]

Figure 1.69 SAMSA is an anhydride compound containing a protected thiol. Reaction with protein amine groups yields amide bond linkages. Deprotection of the acetylated thiol produces free sulfhydryl groups for conjugation. Figure 1.69 SAMSA is an anhydride compound containing a protected thiol. Reaction with protein amine groups yields amide bond linkages. Deprotection of the acetylated thiol produces free sulfhydryl groups for conjugation.
SAMSA-fluorescein, 5- [2(and 3)-5-(acetylmercapto)-succinoyl]amino fluorescein, is a fluorescent probe containing a protected sulfhydryl group. In its protected state, the compound is unre-active. The acetyl-protecting group can be removed by treatment with dilute NaOH at pH 10.0 (Figure 9.9). The resulting free sulfhydryl derivative can be used to label thiol-reactive crosslinkers or to couple with sulfhydryl residues on proteins and other molecules. After activating... [Pg.410]

Synthesis of the Palmitoylated and Farnesylated C-Terminal Lipohexapeptide of the Human N-Ras Protein by Employing an Enzymatically Removable Urethane Protecting Group, H. Waldmann, E. Nagele, Angew. Chem. 1995,107, 2425-2428, Angew. Chem. Int. Ed. 1995, 34, 2259-2262. [Pg.381]

Synthesis of Characteristic Lipopeptides of Lipid Mode-fied Proteins Employing the Allyl Ester as Protecting Group, T. Schmittberger, A. Cotte, H. Waldmann, Chem Commun 1998, 937-940. [Pg.381]

Sequence inversion and racemization have been associated with uncatalyzed formation of the cyclic dipeptides and has been shown to greatly complicate the kinetics of formation. Cyclic dipeptide formation, by uncatalyzed processes, is rapid enough to pose an apparent threat to the stability of proteins and a possible rationale for the posttranslational N-acetylation of proteins that have been observed in higher organisms. The rate of DKP formation will also depend on the carbonyl ester protecting groups or the structures of the peptide-resin linkage in the solid-phase mode. Furthermore, cyclization is a concentration-independent reaction and demands the use of dilute solutions. ... [Pg.681]


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See also in sourсe #XX -- [ Pg.1081 , Pg.1082 ]

See also in sourсe #XX -- [ Pg.1105 , Pg.1106 ]




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Proteins groups

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