Proteins glycoprotein structure

The viral polyprotein comprises four structural proteins followed by six non-structural proteins. The structural proteins are envelope glycoproteins El and E2, Core, and the small P7 ion channel [14, 15]. Another putative protein, F, is also encoded by an alternate reading frame in the structural protein region, but no function for the protein has been identified [16]. The non-structural proteins are designated NS2-N5B. NS2/3 possesses an essential autoprotease activity, but it is still not clear whether NS2 itself has an independent function. The bifunctional NS3 protein consists of an N-terminal... 

Tertiary and quaternary structure of proteins, glycoproteins, denaturation 21.9-21.11... 

Naturally occurring polysaccharides can occur either as individual carbohydrate molecules or in combination with other naturally occurring substances, such as proteins (glycoproteins) and lipids (glycolipids). In all cases the polysaccharide section may have linear or branched chain structures, which often contain the derivatives of both monosaccharides and aminosugars (Figure 1.20). 

Many secretory and membrane proteins are modified in the lumen of the ER. Protein glycosylation, the addition of covalently bound oligosaccharide chains, is a common reaction in the ER lumen and the Golgi complex. Most proteins in the ER lumen destined for secretion from the cell or for transport to other intracellular sites are glycoproteins. The carbohydrate content of glycoproteins can vary from 0.5 to 80% or more of the glycoprotein mass. Glycoprotein structures were described in Chapter 9, and their biosynthesis are covered in Chapter 20. 

Autoantigens. Self-antigens of the organism, which may be targets of autoimmune responses by autoreactive B cells (see -autoantibodies) or T cells, including proteins (e.g. enzymes, structural proteins), glycoproteins (e.g. ( -glycoprotein I), nucleic acids... 

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