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Proteins, chemical synthesis glycosylation

Chemical biology methods have been utilized in three different aspects of prion protein (PrPc) research. The method was used for the structure determination of PrP and the mechanism of PrP-prion (PrPsc) conversion. Furthermore, the question of infectivity can only be answered unequivocally if PrP preparation are used which have been obtained either by heterologous expression or by chemical synthesis. A further line of experiments was directed to simulate PrP posttransla-tional modifications like attachment of a GPI-anchor or glycosylation. Finally, small medicinally compatible molecules have been used to interfere with the PrP-PrPsc conformational switch. In this review we will address these chemical biology aspects of prion research. [Pg.201]

A recent, illustrative example from Okamoto et al. of the extensive applicability of native chemical ligation toward the study of protein stmcture and function is the total chemical synthesis of the glycosylated and non-glycosylated forms of the 73-amino acid chemokine protein CCLl and a 74-amino acid, N-teiminally extended variant, Ser-CCLl [29], The construction of these chemokines was accomplished using a convergent, three-component iterative native chemical Uga-tion approach (see Scheme 4 for a representative example), with the glycosylated... [Pg.33]

Of the three above-mentioned major classes of natural biopolymers, chemical synthesis of nucleic adds (in particular DNA) and proteins had already been achieved by the Merrifield solid-phase synthesis method a computer-controlled automated synthesizer became commerdally available more than 20 years ago. However, the chemical synthesis of polysaccharides like cellulose was far more difficult than that of the former two classes. Polysaccharide synthesis is the repetition of glycosylation, the most fimdamental reaction in carbohydrate chemistry (Scheme 2). [Pg.164]


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See also in sourсe #XX -- [ Pg.2 , Pg.246 ]




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Chemical glycosylations

Glycosyl synthesis

Glycosylated proteins

Glycosylated synthesis

Glycosylation, chemical

Glycosylation, chemical synthesis

Protein chemical

Protein glycosylation synthesis

Proteins chemical synthesis

Proteins glycosylation

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