Proteins arginine-N-methyltransferase

Lin, W.J., Gary J.D., Yang, M.C., Clarke, S. and Herschman, H.R. (1996) The mammalian immediate-early TIS21 protein and the leukemia-associated BTGl protein interact with a protein-arginine N-methyltransferase. The Journal of Biological Chemistry, 271, 15034—15044. 

Cote J, Boisvert E M, Boulanger M C, et al. (2003). Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol. Biol. Cell. 14 274-287. 

Frankel, A., and Clarke, S. (2000). PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain./. Biol. Chem. 275(42), 32974-32982. 

II Inhibition of S-adenosyl-L-methionine protein(arginine) N-methyltransferase by analogs of S-adenosyl-L-homocysteine, Biochim. Biophys. Acta 519 255 (1978). 

Protein phosphatase 2C Protein arginine methyltransferase Protein arginine methyltransferase Arylalkylamine N-acetyltransferase SARS Cov 3C-like protease AHAS... 

Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT (2004) Small molecule regulators of protein arginine methyltransferases. J Biol Chem 279 23892—23899... 

Histone methylation by methyltransferases is another vddely described modification that also plays an important role in regulation of transcriptional activity. Methylation can occur either on arginine or on lysine residues in the N-termini of histones and therefore this group of enzymes can be separated into protein arginine methyltransferases (PRMTs) and lysine methyltransferases (KMTs). 

Dacwag, C.S., Ohkawa, Y, Pal, S., Sif S. and Imbalzano, A.N. (2007) The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Molecular and Cellular Biology, 27, 384-394. 

Protein (arginine) Methyltransferase. The enzyme(s) which methylates arginine residues of proteins was named protein methylase I by Paik and Kim (202). The recommended name is protein (arginine) methyltransferase (S-adenosyl-L-methionine protein N-methylttransferase, EC 2.1.1.23). The enzyme(s) catalyzes the reaction... 

Just as with protein (arginine) methyltransferase, it is likely that there are several protein (lysine) methyltransferases. Neurospora and wheat germ cytochrome cs contain only c-N-trimethyllysine (196), while pea embryo histone III and bovine retina opsin contain either c-N-mono-or c-N-dimethyllysine, but not c-N-trimethyllysine (211). Flagella protein from Salmonella serpens contains only c-N-monomethyllysine (212). 

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