Small-molecule regulators

Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT (2004) Small molecule regulators of protein arginine methyltransferases. J Biol Chem 279 23892—23899... 

Cheng, D., Yadav, N., King, R.W., Swanson, M.S., Weinstein, E.J. and Bedford, M.T. (2004) Small molecule regulators of protein arginine mefhyltransferases. The Journal of Biological Chemistry, 279, 23892—23899. 

Catabolite repression is a two-part system. The first component is the small-molecule regulator, cyclic AMP. Glucose decreases cyclic AMP synthesis. The second component is cyclic AMP binding protein, CAP. CAP binds cAMP and thereby helps RNA polymerase bind to the promoter. When bound to cAMP, CAP binds to a sequence at the 5 end of the lac promoter. CAP binding bends the DNA, allowing protein-protein contact between CAP and polymerase. It therefore behaves in the opposite manner of repressor. Repressor (LacI) binds to operator DNA only in the absence of its small-molecule ligand, while CAP binds to promoter DNA in the presence of its small-molecule ligand. 

Biological Background of Stem Cells Chemical Approaches to Stem Cell Research Small-molecule regulators of stem cell fate Conclusion... 

Small-Molecule Regulators of Stem Cell Fate... 

Small Molecule Regulation of the TF Environment HDAC Inhibitors... 

Liu KJ, Gestwicki JE, Crabtree GR. Bringing Small Molecule Regulation of Protein Activity to Developmental Systems. 2007. Taylor Francis, Oxford, UK. 

Small Molecules Regulate Expression of Many Bacterial Genes via DNA-Binding Repressors... 

Allosteric Enzyme regulation may occur by the binding of small molecule regulators. When the regulator binds to a site separate from the enzyme-active site, the enzyme is said to be allosteric. 

Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc. Natl Acad. Sci. U.S.A., 104, 19023-19028. 

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