ATP-Dependent Chromatin Remodeling

Chromatin remodeling, nucleosome remodeling, and nucleosome disruption are general terms that have been used to summarize a number of changes in chromatin structure. Often, these terms are used to define any event that alters the nuclease sensitivity of a region of chromatin, as nuclease sensitivity is a frequendy used marker of changes in chromatin structure. However, there have been other in vitro assays devised to 

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THE MANY FUNCTIONS OF ATP-DEPENDENT CHROMATIN REMODELLING FACTORS... 

Havas K, Flaus A, Phelan M, Kingston R, Wade PA, Lilley DM, Owen-Hughes T (2000) Generation of superhelical torsion by ATP-dependent chromatin remodeling activities. Cell 103 1133—1142 Henikoff S, Ahmad K (2005) Assembly of variant histones into chromatin. Annu Rev Cell Dev Biol 21 133-153... 

Herrera RE, Chen E, Weinberg RA (1996) Increased histone HI phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc Natl Acad Sci USA 93(21) 11510-11515 Hirota T, Lipp JJ, Toh BH, Peters JM (2005) Histone H3 serine 10 phosphorylation by Aurora B causes HPl dissociation from heterochromatin. Nature 438(7071) 1176—1180 Horn PJ, Carruthers LM, Logie C, Hill DA, Solomon MJ, Wade PA, Imbalzano AN, Hansen JC, Peterson CL (2002) Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes. Nat Struct Biol 9(4) 263—267... 

Tsukiyama, T. (2002) The in vivo functions of ATP-dependent chromatin-remodelling factors. Nat. Rev. Mol. Cell Biol. 3, 422-429. 

Whitehouse, I., Flaus, A., Havas, K., and Owen-Hughes, T. (2000) Mechanisms for ATP-dependent chromatin remodeling. Biochem. Soc. Trans. 28, 376-379. 

Wang, W. (2003) The SWI/SNF family of ATP-dependent chromatin remodelers similar mechanisms for diverse functions. Curr. Top. Microbiol. Immunol. 274, 143-169. 

Xue, Y., Wong, J., Moreno, G.T., Young, M.K., Cote, J., and Wang, W. (1998) NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol. Cell 2, 851-861. 

Tsukiyama, T., Palmer, J., Landel, C.C., Shiloach, J., and Wu, C. (1999) Characterisation of the imitation switch family of ATP-dependent chromatin remodeling factors in Saccharomyces cerevisiae. Genes Dev. 13, 686-697. 

Generation of superhelical torsion by ATP-dependent chromatin remodeling activities. Cell 103, 1133-1142. 

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