Protein structure prediction approaches

Ihe rule-based approach to protein structure prediction is obviously very reliant on th quality of the initial secondary structure prediction, which may not be particularly accurate The method tends to work best if it is known to which structural class the protein belongs this can sometimes be deduced from experimental techniques such as circular dichroism... 

GJ Barton. Protein sequence alignment and database scanning. In MJE Sternberg, ed. Protein Structure Prediction A Practical Approach. Oxford, UK IRE Press at Oxford Univ Press, 1998. 

Unger R (2004) The Genetic Algorithm Approach to Protein Structure Prediction 110 153-175... 

J. Skolnick et al., TOUCHSTONE a unified approach to protein structure prediction. Proteins 53(6), 469 179 (2003)... 

Ginalski, K., Elofsson, A., Fischer, D., and Rychlewski, L. 2003. 3D-Jury A simple approach to improve protein structure predictions. Bioinformatics 19(8) 1015-1018. 

The Genetic Algorithm Approach to Protein Structure Prediction... 

It seems as if the protein structure prediction problem is too difficult for a naive pure implementation of GAs. The direction to go is to take advantage of the ability of the GA approach to incorporate various types of considerations when attacking this long-lasting problem. 

One approach to the protein structure prediction is to classify the folding patterns of globular proteins. This is based on the observation from examining known tertiary structures that the variety of protein folding patterns is significantly restricted. Therefore, it is likely that a protein may belong to one of the previously identified folding patterns. 

Holbrook, S. R., Dubchak, I. Kim, S.-H. (1993). PROBE A computer program employing an integrated neural network approach to protein structure prediction. Biotechniques 14,984-9. 

Maggiora, G. M., Mao, B., and Chou, K. C., Theoretical and Empirical Approaches to Protein-Structure Prediction and Analysis. 35... 

Theoretical and Empirical Approaches to Protein-Structure Prediction and Analysis... 

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