Protein release kinetics polymer concentration effects

The release kinetics of proteins may also be increased or decreased by varying the concentration of polymer in the formulation. In general, as the concentration of polymer increases in a formulation, the release of any protein is retarded as the density of the polymeric matrix increases. This effect is more prominent in the initial release of dmg and is exemplified in Fig. 2 which shows the cumulative release profiles for formulations of increasing PLA concentration that were incorporated with follicle-stimulating hormone (FSH). In vitro analysis was done as discussed in Section 2.1,... 

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