Protein production, in transgenic plants

Protein Production in Transgenic Plants Development and Commercialization... 

Yang, J., Barr, L. A., Fahnestock, S. R., and Liu, Z. B. (2005). High yield recombinant silk-like protein production in transgenic plants through protein targeting. Transgenic Res. 14,313-324. 

Table 3 Key patents for protein expression in transgenic plant production systems (Note The associated company relates to the company associated with commercialization of the patent)...

The most widely studied therapeutic proteins produced in plants include monoclonal antibodies for passive immunotherapy and antigens for use as oral vaccines [40]. Antibodies against dental caries, rheumatoid arthritis, cholera, E. coli diarrhea, malaria, certain cancers, Norwalk virus, HIV, rhinovirus, influenza, hepatitis B virus and herpes simplex virus have been produced in transgenic plants. However, the anti-Streptococcus mutans secretory antibody for the prevention of dental caries is the only plant-derived antibody currently in Phase II clinical trials [40]. Until recently, most antibodies were expressed in tobacco, potato, alfalfa, soybean, rice and wheat [9], It has been estimated that for every 170 tons of harvested tobacco, 100 tons represents harvested leaves. A single hectare could thus yield 50 kg of secretory IgA [3, 41]. Furthermore, it has been estimated that the cost of antibody production in plants is half that in transgenic animals and 20 times lower than in mammalian cell cul-... 

For these reasons, as well as the fact that additional tried-and-tested expression systems are already available, production of recombinant therapeutic proteins in transgenic plant systems has not as yet impacted significantly on the industry. 

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