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Protein misfolding cyclic amplification

Protein-Misfolding Cyclic Amplification and Recombinant Protein-Misfolding Cyclic... [Pg.121]

In 2001 Soto and colleagues described a new type of cell-free prion conversion reaction called protein-misfolding cyclic amplification (PMCA) which has greatly improved efficiency, continuity, and sensitivity compared to the initial CFC reactions [11]. In the typical PMCA reaction, crude brain extracts are used as a source of the PrPc which is induced to convert by prions or PrPres in the test sample. Under these conditions, PrPres can be amplified to levels that are detectable... [Pg.122]

Saborio GP, Permanne B, Soto C (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411 810-813... [Pg.166]

See other pages where Protein misfolding cyclic amplification is mentioned: [Pg.25]    [Pg.58]    [Pg.69]    [Pg.86]    [Pg.123]    [Pg.136]    [Pg.151]    [Pg.25]    [Pg.58]    [Pg.69]    [Pg.86]    [Pg.123]    [Pg.136]    [Pg.151]    [Pg.71]   


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