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Protein groove accessibility

Nearly all structurally characterized DNA polymerases are found to induce B-A transition in DNA bases adjacent to nucleotide incorporation. This induced A-conformation facilitates sufficient access for the protein to desirable contact points in the DNA minor groove. Negative base-pair displacement in the A-form... [Pg.293]

The study of both heterogeneous catalysts and enzymes is dominated by the concept of the active site. Specifically, in enzymes the active site is known to represent only a small portion of the large protein molecule that is the enzyme [6], The active site may lie at or near the surface, but it may also be buried in an active site groove or crevice that limits access of all but the desired substrate. Clearly, the total surface area of the protein is significantly larger than that of the active site. [Pg.24]

See other pages where Protein groove accessibility is mentioned: [Pg.89]    [Pg.742]    [Pg.123]    [Pg.125]    [Pg.189]    [Pg.165]    [Pg.168]    [Pg.180]    [Pg.56]    [Pg.279]    [Pg.182]    [Pg.86]    [Pg.152]    [Pg.70]    [Pg.119]    [Pg.395]    [Pg.633]    [Pg.789]    [Pg.797]    [Pg.75]    [Pg.305]    [Pg.341]    [Pg.5118]    [Pg.1504]    [Pg.1505]    [Pg.1107]    [Pg.585]    [Pg.230]    [Pg.266]    [Pg.603]    [Pg.786]    [Pg.2]    [Pg.93]    [Pg.29]    [Pg.242]    [Pg.243]    [Pg.104]    [Pg.62]    [Pg.732]    [Pg.743]    [Pg.815]    [Pg.5117]    [Pg.222]    [Pg.1240]    [Pg.305]    [Pg.102]    [Pg.311]    [Pg.124]   
See also in sourсe #XX -- [ Pg.732 ]



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