Protein-energy malnutrition structure

Padula, G., Salceda, S., and Seoane, A. I. (2009). Protein-energy malnutrition contributes to increased structural chromosomal alteration frequencies in Argentinean children. Nutr. Res. 29,35-40. 

In some instances, such as when rats may possess different tissue metabolism and cortical function compared with humans, the rat model may be inappropriately extrapolated to humans. For example, the newborn human has relatively more cortical activity than the rat, so nutrient effects on cortical structures may be underestimated in the rat model. In contrast, the rat has a large and metabolically active hippocampus at birth relative to the human. Thus nutrient perturbations, such as iron deficiency, protein-energy malnutrition, or hypoglycemia, which profoundly affect the rat s hippocampus, may overestimate the effect in humans. 

Kwashiorkor A disease of protein—energy malnutrition in which there is oedema masking the severe muscle wastage, fatty infiltration of the liver and abnormalities of hair structure and hair and skin pigmentation. 

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