Dephosphorylation protein

Protein dephosphorylation is catalyzed by phospho-hydrolases called protein phosphatases. While the number of protein tyrosine kinases is roughly comparable to the number of protein tyrosine phosphatases, protein serine-threonine kinases vastly outnumber the protein serine-threonine phosphatases, of which about 25 different species are known to exist. This relative under-representation may be accounted for by the alternative diversification... 

Postsynaptic forms of synaptic plasticity are also heavily regulated by protein phosphorylation. For example, control of protein dephosphorylation catalyzed by PP1 has... 

Kinase inhibitors such as H7, which inhibits serine threonine kinases, resulted in sustained JAK2/STAT activation, suggesting that besides protein dephosphorylation, protein phosphorylation is also required. Furthermore, both inhibition of protein synthesis with cycloheximide and inhibition of... 

The mechanism of the action of nitrates is not completely known, though it is reasonably likely that within smooth muscle cells, nitrates are transformed into nitrites, which then release NO. This, in turn, reacts with guanylatecyclase, causing increased synthesis of guanosine 3, 5 -monophosphate (cyclic GMP). As a result, a GMP-requiring protein kinase is activated, which results in less phosphorylation of muscle protein. Dephosphorylated muscle proteins are less able to contract, which ultimately results in a reduction of the heart s need for oxygen. 

Protein phosphatase-1 inhibitor-1 IRRRRPTP Protein dephosphorylation... 

The hydrolysis reactions of A -phospho amino acids seen as models for protein dephosphorylation have been studied in Tris-HCl buffer (pH7.5)-DMSO. The reactions were first order and the rates were very much faster than those of simple phosphoamidates. A pentacoordinated phosphorus intermediate is proposed on the reaction pathway.265 The rates of ester exchange reactions of alcohols (nucleoside models) with the oxyphosphorane (299) have been studied and the rates of exchange are much faster for diols than for mono-alcohols.266... 

Arbogast LA, Voogt JL (1995) Hypoprolactinemia decreases tyrosine hydroxylase activity in the tuberoinfund-ibular dopaminergic neurons acutely by protein dephosphorylation and chronically by changes in gene expression. Endocrine 5 801-806. 

Misek, D.E. and Saltiel, A.R. An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol promotes protein dephosphorylation in rat epididymal adipocytes. Endocrinology, 1994, 135, 1869-1876. 

Bemdt, N., Protein dephosphorylation and the intracellular control of the cell number. Eront. BioscL, 4, 22, 1999. 

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