Protein-based machines water required

By the Consilient Mechanism Protein-based Machines Require Water to Function... 

A protein-based machine without water as an integral part of its structure could not function by the consilient mechanism. In other words, water is required in at least one of the two states in order to have a movable cusp of insolubility, and in order for competition for hydration to be relevant there must be adequate water present. The first prerequisite, therefore, in addressing the biological relevance of the consilient mechanism is to assess whether or not water exists within or between the changing structural elements of a protein motor during function. 

The second point addresses the nature of elastic force development in relation to imder-standing efficient energy conversion. If the energy required for chain deformation during elastic force development becomes lost to other parts of the protein and to the surrounding water, then so too is efficient energy conversion lost. In other words, elastomeric force development on deformation in a protein-based machine followed by marked hysteresis on relaxation necessarily denotes an inefficient protein-based machine. 

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