Protein Assembly in Peroxisomes

However, it is already clear that the mechanisms responsible for membrane protein integration into the ER membrane and the inner bacterial membrane do place certain constraints on the allowable structures 

Whether natural proteins with frustrated topologies exist is an open question, but it is likely that another constraint discussed above—the differences in the requirements for inducing a helical hairpin with a lumenal versus a cytoplasmic loop—has helped shape natural membrane proteins. This does not appear to be a very strong constraint, however, and will only become apparent when large numbers of 3D structures have been solved. 

This work was supported by grants from the Swedish Cancer Foundation and the Swedish Research Council. 

Andersson, H., and von Heijne, G. (1993). Sec-dependent and Sec -independent assembly of K. colt inner membrane proteins—the topological rules depend on chain length. EMBOJ. 12, 683-691. 

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