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Protecting groups 2- ethyl

Tpte [2-[(4-tritylphenyl)thio]ethyl] Z = Cbz benzyloxycarbonyl protecting group... [Pg.438]

Section 27 16 Carboxyl groups are normally protected as benzyl methyl or ethyl esters Hydrolysis m dilute base is normally used to deprotect methyl and ethyl esters Benzyl protecting groups are removed by hydrogenolysis... [Pg.1151]

Remove the Z protecting group from the ethyl ester of Z Phe Gly by hydrogenolysis Cou pie with the p mtrophenyl ester of Z Leu then remove the Z group of the ethyl ester of Z Leu Phe Gly... [Pg.1255]

An ether that would not undergo rearrangement to a 3-alkyl derivative during acid-catalyzed removal of — NH protective groups was required to protect the phenol group in tyrosine. Four compounds were investigated (9-cyclohexyl-, (9-isobomyl-, 0-[l-(5-pentamethylcyclopentadienyl)ethyl]-, and O-isopropyltyro-sine. [Pg.155]

As previously discussed, ethyl chlorocarbonate reacts rapidly and selectively with an equatorial 3-hydroxyl group to give the corresponding cathylate. Trityl ethers, usually employed as a selective protecting group for primary hydroxyls, can be prepared from A -3j3-ols by heating with triphenylmethyl chloride in pyridine, and from 5a-3 -alcohols by more prolonged heat-... [Pg.403]

DBU, CH3CN, 140 s. The 2-(4-nitrophenyl)ethyl (Npe) phosphate protective group and the 2-(4-nitrophenyl)ethoxycarbonyl (Npeoc) group are stable to these conditions, but the cyanoethyl group is not. [Pg.187]

A cinnamoylpiperazine is described as an anti anginal agent. The key intermediate 1 can, in principle, be obtained by alkylation of the monobenzyl derivative of piperazine 71 with ethyl bromoacetate (72). Removal of the protecting group then affords the substituted piperazine (73). Acylation of this with 3,4,5-trimethoxycinamoyl chloride gives cinepazet (74). ... [Pg.157]

The enamine protecting group was removed by dissolving 10 grams in aqueous acetone (250 ml water to 250 ml acetone) and vigorously stirring this solution at pH 2.5 for 1 hour. The acetone was removed in vacuo and the ester, which was salted out of the aqueous phase as a sticky yellow gum, was dissolved in ethyl acetate (200 ml) and washed twice with 200 ml portions of 1 N sodium bicarbonate and brine and dried over anhydrous magnesium sulfate. Careful addition of dry ester (about 50 ml) to the dry ethyl acetate layer... [Pg.1437]

A more general method for preparation ofa-amino acids is the amidotnalmatesynthesis, a straightforward extension of the malonic ester synthesis (Section 22.7). The reaction begins with conversion of diethyl acetamidomalonate into an eno-late ion by treatment with base, followed by S 2 alkylation with a primary alkyl halide. Hydrolysis of both the amide protecting group and the esters occurs when the alkylated product is warmed with aqueous acid, and decarboxylation then takes place to vield an a-amino acid. For example aspartic acid can be prepared from, ethyl bromoacetate, BrCh CCHEt ... [Pg.1026]

In order to test the influence of the C-terminus protecting groups on the properties of the resulting polymer, the ethyl, hexyl, and palmityl esters of N-benzyloxycarbonyl-L-tyrosyl-L-tyrosine were synthesized and the corresponding polymers (poly(CTTE),... [Pg.219]

The commercially available biphei rl ketone and ethyl isocyanoacetate underwent a smooth condensation reaction and following protecting group manipulations the hydrogenation snbstrate was produced in excellent yield. ° Examination of the asymmetric hydrogenation of material produced using this protocol revealed that the... [Pg.74]

A variety of cleavage conditions have been reported for the release of amines from a solid support. Triazene linker 52 prepared from Merrifield resin in three steps was used for the solid-phase synthesis of aliphatic amines (Scheme 22) [61]. The triazenes were stable to basic conditions and the amino products were released in high yields upon treatment with mild acids. Alternatively, base labile linker 53 synthesized from a-bromo-p-toluic acid in two steps was used to anchor amino functions (Scheme 23) [62]. Cleavage was accomplished by oxidation of the thioether to the sulfone with m-chloroperbenzoic acid followed by 13-elimination with a 10% solution of NH4OH in 2,2,2-trifluoroethanol. A linker based on l-(4,4 -dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) primary amine protecting group was developed for attaching amino functions (Scheme 24) [65]. Linker 54 was stable to both acidic and basic conditions and the final products were cleaved from the resin by treatment with hydrazine or transamination with ra-propylamine. [Pg.198]


See other pages where Protecting groups 2- ethyl is mentioned: [Pg.1239]    [Pg.463]    [Pg.435]    [Pg.299]    [Pg.1239]    [Pg.463]    [Pg.435]    [Pg.299]    [Pg.155]    [Pg.156]    [Pg.235]    [Pg.1137]    [Pg.362]    [Pg.210]    [Pg.144]    [Pg.280]    [Pg.477]    [Pg.87]    [Pg.1137]    [Pg.265]    [Pg.457]    [Pg.459]    [Pg.789]    [Pg.30]    [Pg.181]    [Pg.190]    [Pg.413]    [Pg.28]    [Pg.111]    [Pg.157]    [Pg.14]    [Pg.192]    [Pg.138]    [Pg.255]    [Pg.67]    [Pg.220]    [Pg.124]    [Pg.286]    [Pg.269]    [Pg.160]   
See also in sourсe #XX -- [ Pg.4 , Pg.285 ]




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