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Phosphate group, protection

A number of standard synthetic reference books are available. A review article by Kossell and Seliger discusses protective groups used in oligonucleotide syntheses, including protection for the phosphate group, which is not included in this book, and a series of articles describe various aspects of protective group chemistry. [Pg.4]

The SEM ester was used to protect a carboxyl group where DCC-mediated esterification caused destruction of the substrate. It was formed from the acid and SEM chloride (THF, 0°, 80% yield) and was removed solvolytically. The ease of removal in this case was attributed to anchimeric assistance by the phosphate group. Normally SEM groups are cleaved by treatment with fluoride ion. Note that in this case the SEM group is removed considerably faster than the phenyl groups from the phosphate. ... [Pg.237]

See other pages where Phosphate group, protection is mentioned: [Pg.104]    [Pg.167]    [Pg.38]    [Pg.104]    [Pg.167]    [Pg.38]    [Pg.216]    [Pg.219]    [Pg.224]    [Pg.303]    [Pg.384]    [Pg.391]    [Pg.660]    [Pg.661]    [Pg.662]    [Pg.663]    [Pg.664]    [Pg.666]    [Pg.668]    [Pg.670]    [Pg.672]    [Pg.674]    [Pg.676]    [Pg.678]    [Pg.680]    [Pg.682]    [Pg.684]    [Pg.686]    [Pg.688]    [Pg.690]    [Pg.692]    [Pg.694]    [Pg.696]    [Pg.698]    [Pg.700]   
See also in sourсe #XX -- [ Pg.934 ]



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