Proteases crystals

Selk, L. Clawson, J. Schneider, and S. Kent, Conserved folding in retroviral Protease Crystal structure of a synthetic HIV-1 protease, Science 245 616 (1989). 

Murthy, H. M., Qum, S. and Padmanabhan, R. (1999). Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. J. Biol. Chem. 274, 5573-5580. 

Complex Eco Protease Crystallization conditions Asymmetric unit contents Space group... 

Wlodawer A, Miller M, Jaskdlski M, Sathyanarayana BK, Baldwin E, Weber IT, et al. Conserved folding in retroviral proteases crystal structure of a synthetic HlV-1 protease. Science 1989 245 616-621. 

Figure IS. (a) Stereoview of the contour at —5 kcal/mol for the GRID calculation using a water probe (cyan) and the HIV-1 protease crystal structure [72]. Inhibitor 29 (yellow, first binding mode), an inserted water molecule (red), and Asp29 (magenta) are shown, (b) Stereoview of the contour at —5 kcal/mol for the GRID calculation using a water probe (cyan) and the HIV-l protease crystal structure [72]. Inhibitor 29 (yellow, second binding mode), an inserted water molecule (red), and Gly48 (magenta) are shown.

Figure 16. Stereoview of 31 (black lines) bound in the HIV-1 protease crystal structure [75]. Asp25/ Aspl25 and He50/Ilel50 are displayed (gray lines).

Protease crystal complexes with Lopinavir and DMP 450 exhibited completely different binding modes [250]. Another study of high resolution crystal struc-... 

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