Prostaglandins for Ophthalmic Use

BImatoprost. Bimatoprost (Lumigan) is supplied as a sterile 0.03% ophthalmic solution in 2.5- and S.O-mL sizes. The recommended dosage of bimatoprost is limited to one drop into the affected eye once daily in the evening. Increased use may decrease its beneftcial effect. If used concurrently with other lOP-lowering drugs, a waiting period of S minutes should separate administrations. 

Latanoprost Latanoprost (Xalatan) is available as a 0.005% sterile ophthalmic solution in a 2.S-mL dispenser bottle. Latanoprost is also marketed as a combination ophthalmic product with the /3-adrenergic blocking agent timolol, which apparently enhances lOP-lowering by decreasing the production of aqueous humor. Cautions and side effects are similar to those for other ophthalmic prostanoids. 

Travoprost. Travoprost (Travatan) is supplied as u 2.5-mL sterile 0.(X)4% ophthalmic solution in a 3.5-mL ran-tainer. Travoprost is claimed to be the most potent and FP-specific analogue in this product category. Cautions and side effects are similar to tho.se given above. 

Unoprostone. Unoprostone (Rc.scula) is supplied as a 0.15% sterile ophthalmic solution. Unoprostone Is somewhat unusual, in that it is a docosanoid (22-carbon atom) PGF. . analogue marketed as the isopropyl ester. The natural 1. -position alcohol is oxidized to the ketone, as would be ci. pected to occur in vivo. Cautions and side eflecis are similar to those given above. 

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