Prospects for Multivalent Drugs

In analogy to sulfated multivalent glycoconjugates (Fig. 6.26), it was possible to synthesize a simple polysulfated heparin analogous structure [97]. Recently, a highly active anti-inflammatory interaction with dPGS (Fig. 6.27) was discovered that bound other inflammatory mediators in the nanomolar range of L- and P-selectins as well as in an in vivo mouse model with contact dermatitis that was as effective as the commercial glucocorticoid prednisolone [105]. 

The great advantages of dPGS are that it is easily available on a large scale and it is possible to conjugate effector molecules, for exanple, dyes and drugs [111]. 

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