Propranolol Aminophylline

Ford, J. L., Rubinstein, M. H., and Hogan, J. E. (1985), Propranolol hydrochloride and aminophylline release from matrix tablets containing hydroxypropyl methyl cellulose, Int. /. Pharm., 24,339-350. 

Clinically important, potentially hazardous interactions with acenocoumarol, alfuzosin, aminophylline, anisindione, anticoagulants, buprenorphine, butorphanol, caffeine, carmustine, dobazam, cocoa, dicumarol, dofetilide, duloxetine, epirubicin, eszopiclone, fentanyl, floxuridine, fluorouracil, galantamine, gliclazide, hydromorphone, itraconazole, ketoconazole, lidocaine, meptazinol, midazolam, mizolastine, modobemide, morphine, narcotic analgesics, oxprenolol, oxycodone, pentazocine, phenytoin, posaconazole, prednisone, propranolol, sufentanil, tolazoline, warfarin, xanthines, zaleplon, zofenopril, zolmitriptan, zolpidem... 

Clinically important, potentially hazardous interactions with alcohol, aminophylline, aspirin, chlordiazepoxide, diazepam, lidocaine, phenytoin, propranolol, warfarin... 

A study in 8 healthy subjects (5 of whom smoked 10 to 30 cigarettes daily) found that the clearance of a single 5.7 to 6.4 mg/kg dose of theophylline (as intravenous aminophylline) was reduced by 37% by propranolol 40 mg every 6 hours, when compared with theophylline alone. Metopro-lol 50 mg every 6 hours did not alter the clearance in the group as a whole, but the smokers had an 11% reduction in clearance. Another study, in 7 healthy subjects, found that the steady-state plasma clearance of theophylline was reduced by 30% by propranolol 40 mg every 8 hours, and by 52% by propranolol 240 mg every 8 hours. However, a further study found no significant pharmacokinetic interaction between theophylline and propranolol. Three other studies found that the cardioselective beta blockers atenolol 50 to 150 mg, - and bisoprolol 10 mg, and the non-se-... 

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