Cardiac arrest propofol

Propofol dose-dependently reduced the threshold for lidocaine-induced convulsions in rats (82). Higher doses of propofol completely abolished convulsions. However, there was no difference in the dose of lidocaine that caused cardiac arrest and death, when it was given with three different propofol infusions and placebo. 

Five adults with head injuries inexplicably had fatal cardiac arrests in a neurosurgical intensive care unit after the introduction of a sedation formulation containing an increased concentration of propofol (72). There were striking similarities with the previously reported syndrome of myocardial failure, metabolic acidosis, and rhabdomyolysis in children who received high-dose propofol infusions for more than 48 hours. 

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