Propionitrile, /9-ethoxy

Propionic anhydride, 21, 14 Propionitrile, /3-ethoxy-, 23, 33 Propionyl chloride, 24, 30 Propiophenone, /3-diethy lamino-, 23,... 

The mixture is then fractionally distilled until the temperature reaches 140°. The first fraction boiling at 75-95° consists mostly of alcohol and water, and is discarded. The fraction boiling between 95° and 140° contains water and 25-30 g. of j8-ethoxy-propionitrile. This is extracted twice with 50-cc. portions of benzene, and the benzene extracts are added to the cooled residue in the distilling flask. The mixture is filtered (Note 2), the solid material is washed with 75 cc. of benzene, which is added to the filtrate, and the whole is distilled. The fraction boiling at 169-174° is collected it weighs 178-200 g. (52-58 per cent of the theoretical amount). 

Propionic acid, /J-(chloroformyl)-, METHYL ESTER, 25, 19 Propionic acid, /J,/S -methyliminobis, DIETHYL ESTER, 20, 35 Propionic anhydride, 21, 14 Propionitrile, /3-amino-, 27, 3 Propionitrile, 6-ETHOXY-, 23, 33 Propionitrile, 6,6 -iminodi-, 27, 3 Propionyl chloride, 24, 30 Propiophenone, 6-diethylamino-, 23, 31... 

Ethyl 3-ethoxy-a-nitroacrylate with 1,1-diphenylhydrazine in ethanol followed by heating has been shown to give l,4-bis(diphenylamino)-2,5-diethoxycarbonyl-l,4-dihydropyrazine (1586). A small amount of 2,5-dicyano-l,4-bis(dimethylamino)-1,4-dihydropyrazine was obtained from the reaction of 2-chloro-3-(2, 2-dimethyl-hydrazino)propionitrile [(Me)2NNHCH2CH(Cl)CN] with sodium hydride (1587). Hexaalkyl-l,4-dihydropyrazines and other 1,4-dialkyl-1,4-dihydropyrazines can be obtained by thermolysis of the products of reaction of a-(alkylamino)carboxylic acid esters with alkylmagnesium bromide. Thus the reaction of ethyl a-s-butyl-aminopropionate with ethylmapesium bromide, followed by heating in vacuo to 250-300°, gave 2,5-dimethyl-3,6-diethyl-l,4-di-s-butyl-l,4-dihydropyrazine (1588). 

It is eomparatively a shorter course of reaetion whereby cinnamonitrile is prepared by the interaetion of 3, 4, 5-trimethoxy-benzaldehyde with 3-ethoxy propionitrile with the elimination of a mole of water. The resulting product on treatment with guanidine affords the formation of trimethoprim directly. 

Ether, 2-chloro-o,a,a-trifluoro-p-tolyl 3-ethoxy-4-nitrophenyl. See Oxyfluorfen Ether cyanatus. See Propionitrile Ether, decyl methyl. See Decyl methyl ether Ether, 2,4-dichlorophenyl p-nitrophenyl. See Nitrofen... 

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