Propene oxide 3.3.3- trichloro

Rearrangement of the epoxides to phenols competes with hydration to dihyd-rodiols. The hydration is catalyzed by the microsomal enzyme epoxide hydrolase 362). Dihydrodiols are not formed in the absence of epoxide hydrolase or in the presence of inhibitors of epoxide hydrolase such as l,l,l-trichloro-2,3-propene oxide (TCPO) 138, 203, 417). The dihydrodiols are formed stereospecifically from the 4,5-, 7,8-, and 9,10-epoxides as the (—)-trans isomers 416, 506). 

Abbreviations used CC, column chromatography TLC, thin-layer chromatography HPLC, high-pressure liquid chromatography ESR, electron spin resonance 3-MC, 3-methylcholanthrene TCPO, l,l,l-trichloro-2,3-propene oxide BaP, benzo[a]pyrene BeP, benzo[e]pyrene x = yes. 

Salts of the [UC16] ion have been prepared by precipitation from thionyl chloride solutions of U(V) which were in turn prepared by the prolonged (2 weeks) refluxing of U03 with thionyl chloride3 or by the addition of solid UC15 TCAC, where TCAC = trichloro-acryloyl chloride.4 This latter extremely moisture-sensitive compound was in turn prepared by the reaction of U3 O 8 with hexachloro-propene.1,4 The method of preparation described here,2 which is applicable to the preparation of certain salts of the [UC16] ion, is based on chlorine oxidation in nitromethane solutions of the easily prepared and stored [UC16]2- salts. Some of the known salts of... 

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