Promazines

Substituted phcnothiazines form an important group of tranquillizers, e.g. chlor-promazine. Some, e g. promethazine, have powerful antihistamic activity. 

The parent drug of this series, promazine (24), was prepared originally as an antihistamine. Following the identification of the more potent chloro analog as an antipsychotic, it too came into use for that indication. The drug is prepared by straightforward alkylation of phenothiazine with w-C3-chloropropyl)di-methylamine by means of sodium hydride in xylene. ... 

C5H12CIN 109-54-6) see Acepromazine Bencyclane Benzydamine Chlorpromazine Citalopram Clomipramine Dimetacrine Imipramine Promazine Prothipendyl Triflupromazine... 

C,2Hi,NS 92-84-2) see Alimemazine Aminopromazine Dimethoxanate Dixyrazine Fenoverine Mequitazine Methdilazine Oxomemazine Pecazine Perazine Profenamine Promazine Promethazine Propyramazine... 

Fig 1 Chromatogram of imipramine and phenothiazine derivatives after staining with Forrest reagent [4] 1 = imipramine, 2 = desipramine, 3 = clomipramine, 4 = lofepramine, 5 = trimipramine, 6 = thioridazine, 7 = chlorphenethazine, 8 = periciazine, 9 = promazine, 10 = promethazine. 

Immediately after dipping perphenazine (h/ f 28-33) appeared as pink-colored, fluphenazine (hRj 30-35), dixyrazine (hRj 33-38) and verophene (= promazine, hRf 38-43) as skin-colored and periciazine (h/ f 35-40) as orange, promethazine (h/ f 43-48) as bright pink, alimemazine (h/ f 60-65) as skin-colored and dibutil (etho-propazine, hRf 75-80) as pink-colored chromatogram zones on a colorless background (Fig. 2). The colors faded after some time. 

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