QT interval, prolonged

Domperidone minimally crosses the BBB it acts in the CTZ which lies outside of the BBB. As such, domperidone is less likely to cause the centrally-mediated adverse effects seen with metoclopramide and has an estimated overall incidence of 5% to 10%.1,30 However, domperidone has been associated with prolonged QT intervals, cardiac arrhythmias, and sudden death.31 It should not be used for patients with underlying long QT interval or for those on other medications that prolong the QT interval. Both metoclopramide and domperidone can cause hyperprolactinemia, galactorrhea, and gynecomastia. 

Cardiovascular manifestations result in ECG changes characterized by a prolonged QT interval and symptoms of decreased myocardial contractility often associated with heart failure. 

The QT interval (measured from the beginning of the Q wave to the end of the T wave of the surface electrocardiogram) reflects the duration of individual action potentials in cardiac myocytes (Figure 3.1) indeed, a prolongation of the action potential duration (APD) of myocytes will result in a prolonged QT interval. 

The congenital form of long QT syndrome is characterized by a prolonged QT interval in the electrocardiogram and TdP [28-30]. Many patients with this syndrome... 

Darpo, B. (2001) Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. European Heart Journal Supplements, 3, K70-K80... 

Cavero, I., Mestre, M., Guillon, J.M. and Crumb, W. (2000) Drugs that prolong QT interval as an unwanted effect assessing their likelihood of inducing hazardous cardiac dysrhythmias. Expert Opinion on Pharmacotherapy, 1, 947-973. 

Haloperidol decanoate (Haldol Decanoate) Antipsychotic Inj 50,100 mg/mL 25-100 mg IM q4 weel long acting. Reduce dose in elderly extrapyramidal symptoms, alpha-blocking effects, high doses may prolong QT interval. 

Cardiovasciilar system - in vitro systems for potential to prolong QT interval, effects on heart and blood vessels, anaesthetised and conscious (reflexes intact) animals with effects on heart rate, blood pressure, ECG... 

Bepridll History of serious ventricular arrhythmias uncompensated cardiac insufficiency congenital QT interval prolongation use with other drugs that prolong QT interval. 

QTprolongation Administer methadone with particular caution to patients already at risk for development of prolonged QT interval... 

Cardiac e ecfs. Ventricular arrhythmias in individuals with prolonged QT intervals have occurred with macrolide products. 

NAG, w/ or w/in 2 wk of D/C an MAOI Di p Caps SE t BP, tach, wt loss, sexual dysfxn EMS Use caution w/ albuterol can t CV effects monitor for liver injury (RUQ pain, h atomegaly, jaundice) t risk of suicidal thoughts OD Reports limited but may cause xCTostomia (dry mouth), anxiety, prolonged QT interval and Szs symptomatic and supportive... 

Astemizole and terfenadine are known to aggravate cardiac arrhythmic disorders especially of the prolonged QT-interval type. Their use should be avoided at least in susceptible patients. 

Contraindications Sick sinus syndrome/second- or third-degree AV block (except in presence of pacemaker), severe hypotension (less than 90mmFIg, systolic), history of serious ventricular arrhythmias, uncompensated cardiac insufficiency, congenital QT interval prolongation, use with other drugs prolonging QT interval... 

Prolonged QT interval, seizures, and arrhythmias have been reported. Patient/Famiiy Education... 

Ventricular arrhythmias and prolonged QT interval occur rarely with the IV drug... 

Overdose may increase QRS duration, prolong QT interval, cause conduction disturbances, reduce myocardial contractility, and cause hypotension. 

Bradycardia, CHF, hypotension, bronchospasm, hypoglycemia, prolonged QT interval, torsades de pointes, ventricular tachycardia, and premature ventricular complexes may occur... 

Contraindications Angle-closure glaucoma, blood dyscrasias, cardiac arrhythmias, cardiac or hepatic impairment, concurrent use of drugs that prolong QT interval, severe CNS depression... 

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