Prokaryotes regulation

Madara JL Prokaryotic regulation of epithehal responses by inhibition of 1kB- ubiquitination. Science 2000 61... 

Neish, A.S., Gewirtz, A.T., Zeng, H. et al. 2000. Prokaryotic regulation of epithelial responses by inhibition of I kappa B-alpha ubiquitination. Science 289 1560-1563. 

E. coli Fur and homologs in other prokaryotes regulate the transcription of genes required for iron acquisition, including a host of distinct iron scavenging systems as well as the enzymes for siderophore biosynthesis see Iron Transport Siderophores, Metalloregulation). In addition,... 

Fig. 3.3-2 Prokaryotic regulators of transcription have been adapted for use as eukaryotic transcriptional regulators ...

Regulation in eukaryotes is much more complicated. Prokaryotic regulation is controlled by the choice of G-subunit, the nature of the promoters, and the use of repressors/inducers. In eukaryotes, there are many more promoter elements, transcription factors, and coactivators. In addition, the DNA must be released from histone proteins, so transcription of DNA is linked to histone modifications. 

In cyclic nucleotide-regulated channels, this domain serves as a high-affinity binding site for 3-5 cyclic monophosphates. The CNBD of channels has a significant sequence similarity to the CNBD of most other classes of eukaryotic cyclic nucleotide receptors and to the CNBD of the prokaryotic catabolite activator protein (CAP). The primary sequence of CNBDs consists of approximately 120 amino acid residues forming three a-helices (oA-aC) and eight (3-strands ( 31- 38). 

Prokaryotic genes are often regulated in an on-off man-net in tesponse to simple environmental cues. Some eu-katyotic genes are regulated in the simple on-off man-... 

GENE REGULATION IN PROKARYOTES EUKARYOTES DIFFERS IN IMPORTANT RESPECTS... 

The hypothesis that polar carotenoids regulate membrane fluidity of prokaryotes (performing a function similar to cholesterol in eukaryotes) was postulated by Rohmer et al. (1979). Thus, the effects of polar carotenoids on membrane properties should be similar in many ways to the effects caused by cholesterol. These similarities were demonstrated using different EPR spin-labeling approaches in which the effects of dipolar, terminally dihydroxylated carotenoids such as lutein,... 

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