Projection neurons oscillations

Respiratory rhythmicity is an emergent property of the RCPG resulting from mutual inhibition of inspiratory and expiratory related neurons. A minimal model due to Duffin [1991] postulated the early-burst inspiratory (I) neurons and Botzinger complex expiratory (E) neurons to be the mutually inhibiting pair. Adaptation of the I neurons (e.g., by calcium-activated potassium conductance) results in sustained relaxation oscillation in the network under constant chemical excitation. Both neuron groups are assumed to have monosynaptic inhibitory projections to bulbospinal inspiratory (Ir) output neurons (Figure 11.3). The model equations are ... 

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