Progestogen dosage

Trade name Ethinyl estradiol Regimen, days Dosage, Hg Progestogen Regimen, days a Dosage, mg Launch date Manufacturer... 

J Wright, JD Childers, BL Barclay, PSL Wong, LE Atkinson. Osmotic dosage form comprising an estrogen and a progestogen. US Patent 4,948,593, 1990. 

Not available in a progestogen-only oral dosage form in the United States. 

The introduction of estrogens and progestogens into the environment is a function of the way several factors are combined. The manufactured quantity and the dosage applied (amount, frequency, and duration) combined with the excretion efficiency of the compound and its metabolites, the capability of adsorption and desorption on soil, and the metabolic decomposition in sewage treatment are examples of necessary factors to assess environmental exposure. In general the fate and effect of a substance in the environment is dependent on the distribution into the different natural systems, such as air, water, and solids (soil, particles, sediment, and biota). Information on the physical and chemical properties (Ku, Kd, and Kim vapor pressure) of a compound may help determine whether it is likely to concentrate in the aquatic, terrestrial, or atmospheric... 

The combined use of estradiol and dydrogesterone reduce both diastolic and systolic blood pressures in postmenopausal women in whom the diastolic pressure had been raised (3). Evidence is also advanced from various quarters that adding a progestogen to adequate dosages of an estrogen promotes new bone formation, restores bone that has been lost and reduces the risk of carcinoma of the breast. 

An interference results from excipients in tablets in the DPP assay of some progestogens in combined low-dosage oral contraceptives (CLDOC)[22]. 

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