Progesterone receptors prognostic usefulness

The p53 protein can also been measured by other methods. The LIA method is intended for measurement of the p53 protein in tumor cytosols normally prepared for the routine biochemical measurement of the oestrogen and progesteron receptor status. The LIA method has been demonstrated to be useful and to give prognostic information in a breast cancer material (34). The principal laboratory steps are outlined in Table 3. The LIA measurement of the p53 protein has been compared with immunohistochemical expression and cDNA-based sequencing on more than 200 primary breast cancers (Norberg et al., unpublished data). In brief, the LIA technique seems to have the same principal limitations as the immunohistochemical determination, and the sensitivity and specificity is no better than with immunohistochemical determination. 

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