Progesterone, Raman

Examples of solvent-mediated transformation monitoring include the conversion of anhydrous citric acid to the monohydrate form in water [235,236], CBZ with water [237] and ethanol-water mixtures [238,239], and cocrystallization studies of CBZ, caffeine, and theophylline with water [240]. Raman spectroscopy was used to monitor the crystallization rate and solute and solvent concentrations as griseofulvin was removed from an acetone solution using supercritical CO2 as an antisolvent [241]. Progesterone s crystallization profile was monitored as antisolvent was added [242]. 

Wang, F. Wachter, J.A. Antosz, F.J. etal., An investigation of solvent-mediated polymorphic transformation of progesterone using in situ Raman spectroscopy Org. Process Res. Dev. 2000, 4, 391-395. 

FIGURE 3 Concentration profiles measured by in situ Raman spectroscopy during the phase transformation of progesterone Form-ll (O) to Form-1 ( ) The figure was adapted from data presented in reference 73. 

Figure 8.47. Raman spectrum of native form ai- add g tx)pcoteiiL (Bottom) Raman difference spectrum of native tti- acid glycoprotein minus ai acid glycoprotein wMi tiound progesterone. Positions of amino acids with aromatic side chains, wiA respect to their environment or surface of the protein, have been also determined. Cuitosey from Vbdimir Kopecky Jr., ROd er Enrich, Katefina Hofbauoova and Vladimir Baumnic...

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